February 6-7, 2020 - Pembroke College - Oxford, United Kingdom

3rd Human Challenge Trials in Vaccine Development

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This workshop builds on the successes and identified challenges from two prior workshops on the subject of human challenge trials or controlled human infection models (CHIM).  When CHIM are used to inform vaccine development, they can add to what is known from natural history, epidemiology, and pathogenesis studies to speed the vaccine development pathway.  However, there are significant safety, ethical, operational, environmental, and scientific issues in intentionally infecting humans with infectious organisms in controlled settings of clinical trials.  Nonetheless, these trials can be performed safely and ethically both in non-endemic and endemic regions.  Attend this workshop to learn more about these challenging issues and to join in the conversation that will lead to progress and recommendations for enhancing CHIM as tools to develop new and improved vaccines

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CH-1204 Geneva

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